Application | Comment | Organism |
---|---|---|
medicine | AhpCis a critical element of the antioxidant defense system of Mycobacterium tuberculosis and may be suitable target for the development of novel anti-tuberculosis strategies | Mycobacterium tuberculosis |
medicine | AhpD is a critical element of the antioxidant defense system of Mycobacterium tuberculosis and may be suitable target for the development of novel anti-tuberculosis strategies | Mycobacterium tuberculosis |
Cloned (Comment) | Organism |
---|---|
- |
Mycobacterium tuberculosis |
Protein Variants | Comment | Organism |
---|---|---|
C174S | mutant enzyme retains about 10% of the wild-type activity | Mycobacterium tuberculosis |
C176S | mutant enzyme retains about 10% of the wild-type activity | Mycobacterium tuberculosis |
C61S | inactive mutant enzyme | Mycobacterium tuberculosis |
Cys129 | mutant enzyme shows no activity with cumene hydroperoxide | Mycobacterium tuberculosis |
Cys132 | mutant enzyme retains about 5% of the wild-type activity with cumene hydroperoxide | Mycobacterium tuberculosis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.052 | - |
cumene hydroperoxide | pH 7.0, 25°C | Mycobacterium tuberculosis | |
0.091 | - |
7alpha-hydroperoxy-3beta-hydroxycholest-6-ene | pH 7.0, 25°C | Mycobacterium tuberculosis | |
0.132 | - |
7alpha-hydroperoxy-3beta-hydroxycholest-6-ene | pH 7.0, 25°C | Mycobacterium tuberculosis | |
0.15 | - |
trans-pinocarveylhydroperoxide | pH 7.0, 25°C | Mycobacterium tuberculosis | |
0.23 | - |
tert-butyl hydroperoxide | pH 7.0, 25°C | Mycobacterium tuberculosis | |
0.55 | - |
cumene hydroperoxide | pH 7.0, 25°C | Mycobacterium tuberculosis | |
0.86 | - |
trans-pinocarveylhydroperoxide | pH 7.0, 25°C | Mycobacterium tuberculosis | |
1.1 | - |
tert-butyl hydroperoxide | pH 7.0, 25°C | Mycobacterium tuberculosis | |
1.5 | - |
H2O2 | pH 7.0, 25°C | Mycobacterium tuberculosis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | P9WQB5 | alkyl hydroperoxide reductase D (ahpD) | - |
Mycobacterium tuberculosis | P9WQB7 | alkyl hydroperoxide reductase C (ahpC) | - |
Mycobacterium tuberculosis ATCC 25618 | P9WQB5 | alkyl hydroperoxide reductase D (ahpD) | - |
Mycobacterium tuberculosis ATCC 25618 | P9WQB7 | alkyl hydroperoxide reductase C (ahpC) | - |
Purification (Comment) | Organism |
---|---|
- |
Mycobacterium tuberculosis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
a [lipoyl-carrier protein]-N6-[(R)-dihydrolipoyl]-L-lysine + 7alpha-hydroperoxy-3beta-hydroxycholest-6-ene | - |
Mycobacterium tuberculosis | a [lipoyl-carrier protein]-N6-lipoyl-L-lysine + H2O + 7alpha-hydroxy-3beta-hydroxycholest-6-ene | - |
? | |
a [lipoyl-carrier protein]-N6-[(R)-dihydrolipoyl]-L-lysine + 7alpha-hydroperoxy-3beta-hydroxycholest-6-ene | - |
Mycobacterium tuberculosis ATCC 25618 | a [lipoyl-carrier protein]-N6-lipoyl-L-lysine + H2O + 7alpha-hydroxy-3beta-hydroxycholest-6-ene | - |
? | |
a [lipoyl-carrier protein]-N6-[(R)-dihydrolipoyl]-L-lysine + cholesterol hydroperoxide | - |
Mycobacterium tuberculosis | a [lipoyl-carrier protein]-N6-lipoyl-L-lysine + H2O + cholesterol hydroxide | - |
? | |
a [lipoyl-carrier protein]-N6-[(R)-dihydrolipoyl]-L-lysine + cholesterol hydroperoxide | - |
Mycobacterium tuberculosis ATCC 25618 | a [lipoyl-carrier protein]-N6-lipoyl-L-lysine + H2O + cholesterol hydroxide | - |
? | |
a [lipoyl-carrier protein]-N6-[(R)-dihydrolipoyl]-L-lysine + cumene hydroperoxide | - |
Mycobacterium tuberculosis | a [lipoyl-carrier protein]-N6-lipoyl-L-lysine + H2O + cumene hydroxide | - |
? | |
a [lipoyl-carrier protein]-N6-[(R)-dihydrolipoyl]-L-lysine + cumene hydroperoxide | best substrate for AhpD | Mycobacterium tuberculosis | a [lipoyl-carrier protein]-N6-lipoyl-L-lysine + H2O + cumene hydroxide | - |
? | |
a [lipoyl-carrier protein]-N6-[(R)-dihydrolipoyl]-L-lysine + cumene hydroperoxide | best substrate for AhpD | Mycobacterium tuberculosis ATCC 25618 | a [lipoyl-carrier protein]-N6-lipoyl-L-lysine + H2O + cumene hydroxide | - |
? | |
a [lipoyl-carrier protein]-N6-[(R)-dihydrolipoyl]-L-lysine + cumene hydroperoxide | - |
Mycobacterium tuberculosis ATCC 25618 | a [lipoyl-carrier protein]-N6-lipoyl-L-lysine + H2O + cumene hydroxide | - |
? | |
a [lipoyl-carrier protein]-N6-[(R)-dihydrolipoyl]-L-lysine + H2O2 | - |
Mycobacterium tuberculosis | a [lipoyl-carrier protein]-N6-lipoyl-L-lysine + 2 H2O | - |
? | |
a [lipoyl-carrier protein]-N6-[(R)-dihydrolipoyl]-L-lysine + H2O2 | - |
Mycobacterium tuberculosis ATCC 25618 | a [lipoyl-carrier protein]-N6-lipoyl-L-lysine + 2 H2O | - |
? | |
a [lipoyl-carrier protein]-N6-[(R)-dihydrolipoyl]-L-lysine + oleic acid hydroperoxide | poor substrate | Mycobacterium tuberculosis | a [lipoyl-carrier protein]-N6-lipoyl-L-lysine + H2O + oleic acid | - |
? | |
a [lipoyl-carrier protein]-N6-[(R)-dihydrolipoyl]-L-lysine + oleic acid hydroperoxide | poor substrate | Mycobacterium tuberculosis ATCC 25618 | a [lipoyl-carrier protein]-N6-lipoyl-L-lysine + H2O + oleic acid | - |
? | |
a [lipoyl-carrier protein]-N6-[(R)-dihydrolipoyl]-L-lysine + tert-butyl hydroperoxide | - |
Mycobacterium tuberculosis | a [lipoyl-carrier protein]-N6-lipoyl-L-lysine + H2O + tert-butyl alcohol | - |
? | |
a [lipoyl-carrier protein]-N6-[(R)-dihydrolipoyl]-L-lysine + tert-butyl hydroperoxide | - |
Mycobacterium tuberculosis ATCC 25618 | a [lipoyl-carrier protein]-N6-lipoyl-L-lysine + H2O + tert-butyl alcohol | - |
? | |
a [lipoyl-carrier protein]-N6-[(R)-dihydrolipoyl]-L-lysine + trans-pinocarveylhydroperoxide | - |
Mycobacterium tuberculosis | a [lipoyl-carrier protein]-N6-lipoyl-L-lysine + H2O + trans-pinocarveyl alcohol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
peroxiredoxin AhpC | - |
Mycobacterium tuberculosis |
peroxiredoxin AhpD | - |
Mycobacterium tuberculosis |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.013 | - |
trans-pinocarveylhydroperoxide | pH 7.0, 25°C | Mycobacterium tuberculosis | |
0.015 | - |
trans-pinocarveylhydroperoxide | pH 7.0, 25°C | Mycobacterium tuberculosis | |
0.033 | - |
cumene hydroperoxide | pH 7.0, 25°C | Mycobacterium tuberculosis | |
0.035 | - |
tert-butyl hydroperoxide | pH 7.0, 25°C | Mycobacterium tuberculosis | |
0.06 | - |
tert-butyl hydroperoxide | pH 7.0, 25°C | Mycobacterium tuberculosis | |
0.067 | - |
cumene hydroperoxide | pH 7.0, 25°C | Mycobacterium tuberculosis | |
0.085 | - |
H2O2 | pH 7.0, 25°C | Mycobacterium tuberculosis | |
0.088 | - |
H2O2 | pH 7.0, 25°C | Mycobacterium tuberculosis | |
0.147 | - |
7alpha-hydroperoxy-3beta-hydroxycholest-6-ene | pH 7.0, 25°C | Mycobacterium tuberculosis | |
0.178 | - |
7alpha-hydroperoxy-3beta-hydroxycholest-6-ene | pH 7.0, 25°C | Mycobacterium tuberculosis |
General Information | Comment | Organism |
---|---|---|
physiological function | AhpC is a critical element of the antioxidant defense system of Mycobacterium tuberculosis | Mycobacterium tuberculosis |
physiological function | AhpD is a critical element of the antioxidant defense system of Mycobacterium tuberculosis | Mycobacterium tuberculosis |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.017 | - |
trans-pinocarveylhydroperoxide | pH 7.0, 25°C | Mycobacterium tuberculosis | |
0.032 | - |
tert-butyl hydroperoxide | pH 7.0, 25°C | Mycobacterium tuberculosis | |
0.056 | - |
H2O2 | pH 7.0, 25°C | Mycobacterium tuberculosis | |
0.059 | - |
H2O2 | pH 7.0, 25°C | Mycobacterium tuberculosis | |
0.06 | - |
cumene hydroperoxide | pH 7.0, 25°C | Mycobacterium tuberculosis | |
0.087 | - |
trans-pinocarveylhydroperoxide | pH 7.0, 25°C | Mycobacterium tuberculosis | |
0.26 | - |
tert-butyl hydroperoxide | pH 7.0, 25°C | Mycobacterium tuberculosis | |
1.2 | - |
cumene hydroperoxide | pH 7.0, 25°C | Mycobacterium tuberculosis | |
1.35 | - |
7alpha-hydroperoxy-3beta-hydroxycholest-6-ene | pH 7.0, 25°C | Mycobacterium tuberculosis | |
1.62 | - |
7alpha-hydroperoxy-3beta-hydroxycholest-6-ene | pH 7.0, 25°C | Mycobacterium tuberculosis |